This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognizing you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Is there a link between human growth hormone and Creutzfeldt-Jakob disease?
Examining the link between human growth hormone and Creutzfeldt-Jakob disease (CJD)
Challenge
Cadaveric-derived human growth hormone (HGH) was effective in treating growth failure. Between 1963 and 1985, through the federal government’s National Hormone and Pituitary Program (NHPP), HGH was distributed to 250+ physicians.
In 1985, 3 people who received HGH therapy through the NHPP died of Creutzfeldt-Jakob disease (CJD), a rare neurogenerative disease. These cases prompted the federal government to terminate HGH distribution.
Since then, for the National Institute of Diabetes, Digestive, and Kidney Diseases, Westat has been conducting a surveillance study to identify the scope of the CJD problem in recipients of NHPP-provided hormone. Special attention was paid to whether cases started HGH before or after 1977, when a new laboratory purification step was added.
Solution
The HGH recipients and their families were located and surveyed. Death certificates, medical records, and pathology specimens were reviewed for evidence of CJD.
Results
Through the efforts of this study and reports from other sources, 32 confirmed cases of CJD have been identified among NHPP recipients. No cases began treatment after 1977.
Westat continues to analyze and report findings related to CJD and other illnesses.
Senior Expert Contact
Margaret Camarca
Senior Research Associate
-
Perspective
Diverse Journeys: Westat Women in LeadershipMarch 2024
In celebration of Women’s History Month, we’re shining a spotlight on the remarkable women leaders at Westat. Their diverse backgrounds, experiences, and insights have helped…
-
Perspective
Spotlight on Maternal Mental HealthMarch 2024
Mental health conditions are the most common complications during pregnancy and the postpartum period. The Centers for Disease Control and Prevention (CDC) identifies mental health…
-
Perspective
Access to Birthing-Friendly Facilities for Maternal CareFebruary 2024
Preventable maternal mortality in the U.S. has grown considerably and spurred the federal government into action, most noticeably with the development of the White House…