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COVID Vaccines Cut Hospital Risk for Immunocompromised Adults

April 4, 2024

From September 2023 to February 2024, adults with weakened immune systems who had received an updated COVID-19 vaccine were about 1/3 less likely to be hospitalized with COVID-19 compared with those who had not received an updated vaccine, according to new data available in a VISION 2.0 Network paper, recently published in the Centers of Disease Control and Prevention’s (CDC’s) Morbidity and Mortality Weekly Report (MMWR): Interim Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19–Associated Hospitalization Among Adults Aged ≥18 Years with Immunocompromising Conditions — VISION Network, September 2023–February 2024 | MMWR (

Westat authors include Elizabeth A.K. Rowley, DrPH, Zachary A. Weber, PhD, Sarah E. Reese, PhD, Sarah W. Ball, ScD, and Margaret M. Dunne, MSc.

People with weakened immune systems, who are at higher risk for severe COVID-19 and might have decreased response to vaccination, may require additional doses of COVID-19 vaccine. Researchers examined data from the VISION Vaccine Effectiveness (VE) Network to evaluate the effectiveness of the updated 2023-24 COVID-19 vaccines in preventing hospitalization among adults with weakened immune systems.

Everyone 6 months and older should get an updated COVID-19 vaccine, especially people 65 years or older and people with weakened immune systems, who are eligible for additional doses because they are more likely to get very sick with COVID-19.


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