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How do Latina women respond to standard breast cancer treatment?

Strengthening cancer research across Latin America

Cancer is the second leading cause of death worldwide. More than twice as many people die from cancer than from AIDS, malaria, and tuberculosis combined. The National Cancer Institute (NCI) Center for Global Health supports cancer research around the world.

As part of these efforts, NCI selected Westat to manage the initiatives of its United States-Latin America Cancer Research Network (LACRN), starting with the network’s prospective study of the biology and genetics of breast cancer in Latin American women.

The study, entitled Molecular Profiling of Stage II and III Breast Cancer in Latin American Women Receiving Standard of Care Treatment Study, or MPBCS, will help researchers understand how and why women respond differently to standard breast cancer treatment.

To support LACRN and MPBCS, we will, among other responsibilities

  • Provide guidance to study sites on activities related to data management and maintenance of biospecimens (e.g., blood, core biopsy, and surgical resections)
  • Monitor the quality of study and biospecimen data collected by study sites
  • Review the data, conduct harmonization of collected data across study sites, and produce analytic datasets for the production of manuscripts
  • Provide systems support for all cloud-based study data management systems
  • Establish and negotiate 6 subcontract agreements with study sites in Argentina, Brazil, Chile, Uruguay, and Mexico
  • Ensure compliance with all research and data security requirements
  • Purchase and maintain the study inventory of equipment and supplies
  • Maintain the Network’s communication infrastructure, including steering committee discussions and all study protocol, data collection, and workflow documentation
  • Provide regular reporting of study progress and data outcomes and conduct analyses of study data
  • Support planning and conduct of ancillary studies of genetic ancestry in Latin American women

Through the initiatives of LACRN, NCI seeks to build the capacity of Latin American countries to engage in high-quality cancer research.

The results of studies sponsored by LACRN, such as the MPBCS, will also address cancer etiology and treatment questions relevant to Latin American women as well as women everywhere.

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